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Men with a personal or family history of medullary thyroid cancer or thyroid-related conditions should avoid semaglutide, regardless of testosterone therapy, because GLP-1 agonists carry a black-box warning for this population

In clinical trials, the average person taking semaglutide lost anywhere from 7% to over 17% of their body weight within a year and a half, depending on the dose of semaglutide

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