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The most frequently reported side effects typically include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which affect a significant proportion of patients, particularly during dose escalation
Minor variation in vial duration is normal and does not affect results
In the STEP 1 trial published in The New England Journal of Medicine , people taking semaglutide lost more than 15% of their body weight over about 16 months
Immunoblotting The total protein from cells or tissues were extracted by RIPA lysis buffer (Beyotime, Shanghai, China)
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