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It enhances blood flow and nutrient transportation in muscles, preventing exercise-related muscle damage
In HFrEF, an issue remains that because GLP-1 RAs have been shown to modestly increase heart rate (2-3 beats per minute) owing to their chronotropic effects (see Mechanisms) (Sun et al., 2015), GLP-1 RA treatment in HFrEF may be problematic considering that, in line with the use of beta-blockers to ameliorate HFrEF (11, 12), heart rate elevations may result in a worse outcome (Rossignol et al., 2015) and may therefore not benefit from the weight-reducing effect of GLP-1 RAs
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Some may take a bit longer, particularly if their dose increases are faster or their digestive system is more sensitive
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