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Tolerogenic DCs are characterized by increased anti-inflammatory markers (IL-10 and TGF- ) and decreased pro-inflammatory cytokines, with a developmental state described as semi-mature ( Metabolic modulation via metformin treatment has also shown promise in inflammatory diseases by inducing tolDCs and driving subsequent Treg generation

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Mitochondrial fusion is necessary to repair cell damage, form networks, and exchange genetic information [311]

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BPC 157, in contrast, induced faster rates of healing and induced full functional restoration, which is also in agreement with the aforementioned studies on tendons (Krivic et al