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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results
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Although the decrease in the GSH/GSSG ratio was contrary to expectations, the achievement of near-normal levels may indicate gradual functional restoration of the redox system
Identification and processing of proglucagon in pancreatic islets
By six months, the participants had lost 12.7% of their body weight on average
PMID 19118377
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