The proteins were neutralized and solvated in 0.15 M NaCl solution using the simple point-charge water model and a box size of 7.0 7.0 7.0 nm 3
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Those who interrupted GLP-1 treatment and subsequently resumed before the end of the three-year trial period experienced less benefit compared to those who stayed on the medication, with longer gaps in treatment corresponding to smaller reductions in cardiovascular risk
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Additionally, a recent study showed a low cardiovascular risk for postload concentrations less than 23 mol/L and an increased risk above 34 mol/L (Reis et al, 1995)
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