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10.1017/S1461145710000738 156 KleinloogJ

Milk thistle is a dietary supplement which is used for hepatitis, indigestion, diabetes, and other conditions

It dissolves under the tongue or against the cheek, absorbing through the oral mucosa rather than passing through the gastrointestinal tract

Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27

These medicines work best when used as ongoing treatment, similar to medicine for high blood pressure or diabetes