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This can be expected to result in GTP depletion

doi: 10.1016/j.bbih.2020.100116 98 SeoS-KKwonB

During wound healing, MMPs play dual roles: they facilitate tissue debridement and cell migration in early healing phases, while excessive or prolonged MMP activity can impair matrix deposition and delay closure

In addition, IGF-1 receptor sensitivity and activation of the post receptor pathway were not evaluated in the majority of the study enrolling long-lived subjects

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