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Renal function should be monitored, as severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment
Various mechanisms have been theorized to describe how dual agonism, as GLP-1 RA, could directly reduce triglycerides hepatocyte storage, lipogenesis and improving hepatic glucose metabolism (96) and promoting lipolysis and fatty acid oxidation (97)
doi:10.1053/j.gastro.2011.02.018 Fras, Juan P et al
It is also important to know that elevated Phase I activity is not always a good thing
If you already have Lyme disease, an oral form should help reduce recurring flare-ups
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