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2 Based on published research evaluating cardiovascular outcomes associated with hormone therapy initiated near menopause in appropriate patient populations

Supplementary Figure 3 Transcriptomic meta-analyses of melatonin receptor and antioxidant pathway expression

In the hypoxic TME, stabilization of HIF-1 not only enhances glycolytic flux through the upregulation of HK2 and PDPK1, but also supports tumor cell motility and invasiveness (77)

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