The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
But fear not
Most evidence preclinical
For example, in a study we referenced earlier, which entailed 52 weeks of tesamorelin administration in patients with HIV, the researchers found the peptide to be generally well tolerated. Importantly, tesamorelin caused no significant elevations in glucose, which would have represented a severe safety hazard given the relationship between hyperglycemia and diabetes.9 26 That being said, there are contraindications and potential side effects: Contraindications with tesamorelin Current research has yet to establish the safety of tesamorelin among women who are pregnant or breastfeeding
A mild shortage might simply require dietary tweaks, whereas severe depletion necessitates immediate, potent B12 injections
The four-amino-acid pineal peptide is most associated in the popular literature with longevity claims