Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations
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Phentermine and similar appetite medications require extra caution because blood pressure, heart history, sleep, anxiety, and medication interactions matter
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Moreover, among patients with T2DM and established cardiovascular disease, some trials reported the additional benefit of a lower rate of major adverse cardiac events (MACE) in patients treated with SGLT2-i (7, 10)