Over time, this leads to a damaged gut lining, reduced microbial diversity, and a chronic inflammatory state
For each system, a citation matrix was constructed, with rows representing unique primary studies and columns representing the included meta-analyses
We're here to make sure that doesn't happen
In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)
Most research subjects are given an ipamorelin dose of 200-300 mcg per day, for 8-12 weeks, followed by a 4 week washout period
Lee et al., 2021)