Complementing randomized trial evidence, extensive real-world observational data from large healthcare databases consistently demonstrate associations between GLP-1 receptor agonist utilization and decreased risks of MALOs involving cirrhosis, hepatic decompensation, HCC, and death from hepatic causes in patients with MASLD and type 2 diabetes
Morning blood pressure surge is associated with arterial stiffness and sympathetic baroreflex sensitivity in hypertensive seniors
Tesamorelin works upstream, at the hypothalamic-pituitary axis level
Cross-indication switches (Wegovy to Mounjaro for diabetes, or Ozempic to Zepbound for obesity) require the appropriate qualifying diagnosis and often a new pre-authorization cycle
This adjustment phase is usually temporary as the body finds a new set point for its metabolism, but it can be disruptive in the early weeks of treatment
Data from liraglutide trials (a closely related GLP-1 agonist) demonstrated approximately a 7% increase in amylase and a 28% to 31% increase in lipase compared to placebo