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doi:10.2147/CIA.S192435
As a general principle, fewer ingredients means fewer unknown interactions, so a two-peptide blend involves less combinatorial uncertainty than a four-peptide one but that is not the same as being safe. A large, separate risk is product quality: these are unregulated research chemicals, and independent testing across the market has found mislabeled, underdosed, or contaminated products
Scientists aren't entirely sure why this is
(5) Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE
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