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Sikiric P, et al

The location of AD is in the brain

Thus, different inhibitors of HSP90 have been developed and tested in clinical trials to target the protein in different types of cancer

Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2) is an oligopeptide drug, orally active and blood-brain barrier-permeable angiotensin IV analog, binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor c-Met

Known as the "Body Protection Compound," it helps reduce pain, speed recovery, and enhance blood flow to damaged tissues, making it a favorite among athletes and those with chronic joint issues

Therefore, certain specific methods to intensify hypoxia within tumors, such as photodynamic [367, 368] and vascular-disrupting agents [370], have been explored