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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 (SGLT2) inhibitors are game-changers in the treatment of T2DM and are currently promoted by major clinical guidelines among potential first-line pharmacological options after failure/intolerance to metformin, especially in individuals with an atherosclerotic cardiovascular disease phenotype (GLP-1 RAs) [174]

Individuals with suicidal ideation or ongoing psychiatric instability require stabilization before starting GLP-1 therapy, as nausea and appetite suppression can complicate mental health management

Step 6: Complete cycle and rest Finish your planned active phase