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This delayed gastric emptying can: Slow bowel movements Increase water absorption in the colon Result in harder stools and more difficult elimination These changes are part of how the medication supports weight loss and appetite regulation, but they can also lead to temporary gastrointestinal discomfort

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Fatigue may result from multiple factors including significant caloric deficit from appetite suppression, metabolic adaptation to weight loss, nutritional deficiencies, gastrointestinal side effects affecting food and fluid intake, and changes in blood glucose levels

Policy GLP-1s act on receptors in many parts of the body, some of which were still figuring out, says endocrinologist Anira Iqbal, MD