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Researchers examine how KPV blocks the nuclear translocation of Nuclear Factor kappa B (NF-$\kappa$B) in both intestinal epithelial cells and active immune cells, subsequently shutting down the transcription and downstream secretion of damaging pro-inflammatory cytokines such as TNF-$\alpha$, IL-1$\beta$, and IL-6
Signal Transduct Target Ther 9:211
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In comparison, those in the placebo group lost only about 23%, or roughly 2.5 kilograms
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