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They provide the most benefit when combined with a healthy diet and regular physical activity

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We also address psychological symptoms, such as mood swings, depression, and anxiety, which often accompany vitamin B12 deficiency

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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors