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Arjmand et al., 2024)
17:96 DOI 10.1186/s12876-017-0652-3
Additionally, these meds may also impact communication between the gut and the brain, reducing signaling that helps tell your body to poop
Danuglipron (dosed twice daily) and orforglipron (once daily) continue in clinical trials, while the clinical development of lotiglipron (once daily) was recently stopped due to elevated transaminase liver enzymes
Its small molecular size allows it to penetrate intestinal epithelial cells directly, which is why it has attracted research interest as an orally deliverable gut-targeted compound
The primary risks are that the medication will lose its potency and fail to work, or that the sterile environment inside the vial has been compromised, leading to a risk of infection
