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Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes
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Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly
Nausea (most common, especially during first 1 to 2 weeks of a new dose) Diarrhea or, just as often, constipation Vomiting (less common but more likely at 9 to 12 mg) Reduced appetite, food noise quieting down (this is the goal, not a side effect) Skin sensitivity (dysesthesia): tingling, prickly feeling, or sunburn-like skin
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These side effects can impact patient tolerability and adherence, potentially limiting the widespread adoption of these drugs in some individuals
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