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In addition to the classical pathway described, a non-classical pathway (caspase-4/5/11-dependent) for NLRP3 inflammasome activation also exists and is involved in the response to DAMPs [272]

Dosage : Safe oral doses typically range from 250 mg to 1,000 mg daily

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Transparency about the regulatory status of the treatment : A responsible doctor will clearly explain whether a proposed treatment is HSA-approved for its intended use, or whether it constitutes off-label use, and will document informed consent accordingly

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