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Patients least suited to treatment with semaglutide tablets would be individuals well controlled with Metformin, individuals not well controlled with Metformin who are overweight but who are willing to take an injectable GLP-1 RA, and patients who are intolerant of the GI side-effects of semaglutide tablets, according to the clinical expert

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This peptide can help heal the lining of the stomach and intestines, making it a potential treatment for conditions like inflammatory bowel disease (IBD) and leaky gut syndrome

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doi: 10.1007/s10585-010-9305-4

Patients with a history of allergic reactions or sensitivities to GLP-1 receptor agonists, pancreatitis, thyroid cancerincluding medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN-2) generally are not suitable candidates for this therapy