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Signs and symptoms: Many common symptoms can be caused by vitamin B12 deficiency, including weakness, tiredness, lightheadedness, heart palpitations, shortness of breath, pallor (pale skin), diarrhea, decreased appetite, nerve problems like numbness or tingling, visual changes and psycho-emotional problems like depression, memory loss or behavioral changes

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JPT's peptide stability guidance makes the same broad distinction: lyophilized peptides can remain stable for months to years when stored properly, while reconstituted materials require tighter handling

MK-677 has been studied in trials lasting 1224 months with generally good tolerance