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This figure is directly comparable to the performance of tirzepatide (Mounjaro) in the SURMOUNT-1 trial, which showed approximately 20.9% weight loss at 72 weeks, and exceeds the approximately 14.9% achieved by semaglutide alone in STEP 1
Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue
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US Department of Agriculture and US Department of Health and Human Services
Some patients see changes earlier
10.1016/j.neuroscience.2004.06.046 158 VinkR.NimmoA
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