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Scientists began tracking the link, but early studies tended to focus on a few main substances, particularly alcohol, tobacco, and cannabis

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Ethics statement The animal study was approved by Lower Saxony State Office for Consumer Protection and Food Safety (LAVES, Oldenburg, Germany)

The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides

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