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Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes
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Dietary supplementation with 1% and 2% glycine to Phase-I HSB increased concentrations of guanidinoacetate and creatine in the kidneys in a dose-dependent manner (Table 1)
Under normal circumstances, insulin maintains the NAD(+)/NADH ratio by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway and inhibiting the forkhead box protein O1/heme oxygenase 1 (Foxo1/Hmox1) pathway, thereby mediating the activation of the sirtuin 1/peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (SIRT1/PGC-1) pathway and regulating mitochondrial physiological functions (27)
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The HPG axis functions through the pulse production of the gonadotropin-releasing hormone (GnRH) from the hypothalamus, which in the pituitary stimulates the production of the follicle-stimulating hormone (FSH), necessary for sperm production (spermatogenesis), and luteinizing hormone (LH), necessary for both testosterone production and spermatogenesis (11, 15)
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