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In the liver, glucagon stimulates fat burning, suppresses new fat production, promotes hepatic fat clearance, and increases energy expenditure through futile cycling and FGF21 signaling

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Funding The research in the authors laboratory was supported by the National Natural Science Foundation of China Grant (No.8217140592, No.81673671) and Special National Key Research and Development Plan (No.2016YFC1306305 J-DX)

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