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A recent meta-analysis study reviewed twelve randomized controlled trials (RCTs) (n = 791) and found that ALC supplementation significantly reduced depressive symptoms in MDD as monotherapy and augmentation compared to placebo, with effect sizes comparable to standard antidepressants and a superior safety profile
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These observations are based on animal and in vitro research models
doi: 10.1152/ajprenal.00597.2019, 29
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