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Jul 7 2025;46(26):2564-2575

Most DPP-4 inhibitors require dose reduction or avoidance in moderate-to-severe renal impairment, and prescribers should consult the relevant Summary of Product Characteristics

Elevated circulating TMAO concentrations have been not only linked to an increased risk of cardiovascular disease but also to an increased risk for type 2 diabetes mellitus and kidney disease (117-119)