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In our studies conducted in a prenatal stress model (PS) of depression in rats, adult PS animals showed a significant decrease in GLP-1R protein levels in the hippocampus after the acute immobility stress [83]
doi: 10.1038/cdd.2014.218 275 KolahgarGSuijkerbuijkSJKucinskiIPoirierEZMansourSSimonsBDet al
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Treatment is not open-ended by default and is reassessed as goals are reached or priorities change
In aging, when melatonin output diminishes, this synchronization is weakened contributing to internal desynchrony and various functional impairments ( To summarize melatonins roles relevant to aging, Table 1 provides an overview of some key functions of melatonin and how they change or impact physiology in older adults
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