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Rare but serious effects can include pancreatitis, gallbladder problems, kidney injury (often linked to dehydration from severe vomiting or diarrhea), severe or persistent abdominal pain, serious allergic reactions, worsening of diabetic retinopathy in people with type 2 diabetes, and low blood sugar especially if semaglutide is combined with insulin or sulfonylureas

No, GLP-1 receptor agonists are not currently indicated as a primary or disease-modifying treatment for Rheumatoid Arthritis (RA)

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Non-oral formulations may be preferable for some patients, particularly if nausea is present

Placebo assignment hits 20-25% of participants in most trials

PMID: 7342494