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The Cranbury, New Jerseybased biotech announced FDA acceptance of its Biologics License Application for RP-L201 (marnetegragene autotemcel), an investigational lentiviral vector (LV)-based gene therapy for LAD-I, a rare, genetic immune disorder that predisposes patients to frequent and often fatal infections

Dovato, which combines the integrase strand transfer inhibitor dolutegravir with the nucleoside reverse transcriptase inhibitor lamivudine, was approved to treat HIV-1 infection in adolescents 12 years and older, making it the first oral, two-drug, single-tablet regimen available for this patient population, according to ViiV

Relative mRNA expression was calculated by Ct method

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Shaking creates foam, and foam means air-liquid interfaces where peptide molecules are subjected to surface tension forces that cause denaturation

With daily dosing over an 8-week protocol, maintaining 10 or more rotation sites ensures adequate tissue recovery between injections