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Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other
The relationship between insulin and diabetes is something that often confuses patients and, frankly, can trip up clinicians as well, so I want to take a moment to trace through the connection carefully
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This can be particularly disheartening for those who have achieved their desired skin tone through supplementation
Semaglutide has additional health advantages beyond those related to weight loss
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