glp 1 blindness A potentially blinding condition is a very rare side effect of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy, Rybelsus), the European Medicines Agency (EMA) concluded. https://www.medpagetoday.com/ophthalmology/generalophthalmology/115938?trw=no Optic Neuropathies and ER-100 –

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ER zinc dysregulation The ER is highly sensitive to perturbations in zinc homeostasis, and disturbances in luminal or cytosolic zinc can initiate maladaptive stress responses that contribute directly to human disease

Even when late-stage data look strong, the FDA still reviews efficacy, adverse events, manufacturing, labeling, contraindications, drug interactions, and risk-management requirements

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Biophysical Res