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A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)
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The global burden has increased substantially over the last twenty years, mirroring the parallel epidemics of obesity and type 2 diabetes mellitus
10.1016/j.fct.2017.07.018 134 OzaM
The unbalanced interaction between oxidants and antioxidants has an impact on reproductive pathologies such as abnormalities in oocyte metabolism endometrial maturation through the activation of nuclear factor-kappa B (NF-) and nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathways, endometriosis, polycystic ovarian syndrome (PCOS), infertility, prenatal development disorders, and complications
Endocrinology 159 , 15701584 (2018)
