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A 2025 narrative review in Clinical Therapeutics found that across 19 real-world studies, oral semaglutide delivered a median HbA1c reduction of around 1% and a median body weight reduction of 2 to 3 kg at six months, while showing a safety profile that was broadly in line with clinical trials (source)

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Thats a meaningful benefit, since diabetes roughly doubles a persons risk of heart disease

Consoli A, Nurjhan N, Capani F, Gerich J