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3.3 Temperature responsive hydrogels A modest but persistent temperature rise occurs within osteoarthritic lesions, most notably in synovial tissue where inflammation and cellular metabolism are heightened ( Under mitochondrial stress, activating transcription factor 5 (ATF5) upregulates mitochondrial chaperones and proteases in chondrocytes

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Wang Z, Shen X, Gao X (2019b) Simultaneous enzyme mimicking and chemical reduction mechanisms for nanoceria as a bio-antioxidant: a catalytic model bridging computations and experiments for nanozymes

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L., & Brenner, C