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In addition, V-9302 and GLS inhibitor CB-839 combination therapy show significant tumor suppression in an HCC xenograft mouse model (Jin et al., 2020)
This effect occurs in approximately 15-20% of users and usually diminishes with continued use
Carter DC, Ho JX
Laboratory research record on GLP-1S [PMID: 42068314] PubMed laboratory record discussing GLP-1S in a research context
While age-related changes are characterized by a slow, progressive loss of muscle mass, this decline could lead to sarcopenia, frailty syndrome, and cachexia in more severe cases
What we have is a plausible biological hypothesis (collagen peptide supplementation provides the amino acid substrates that bone matrix formation depends on, which may be relevant when those substrates are being depleted by rapid weight loss) supported by a strong positive RCT in a related population - and no direct evidence yet in the GLP-1 therapy population specifically
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