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FIGURE 5 3.5 Overcoming delivery barriers with advanced therapeutic systems A significant challenge contributing to the unmet promise of many promising preclinical antioxidant and other oxidative stress-modulating agents is the inefficient and non-targeted delivery of these compounds to the injured myocardium (Shi et al., 2022)

Ross, Sunil Sharma Oncoscience.2015

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Haidar A, Legault L, Messier V, Mitre TM, Leroux C, Rabasa-Lhoret R

Oncology & Immune Support High Dose Vitamin C IV 180 min | 3 medical credits At therapeutic doses, intravenous Vitamin C functions as a potent antioxidant and immune modulator achieving serum concentrations that oral supplementation cannot replicate

The increased shielding thickness beyond standard spacecraft values (average thickness of about 10 g cm 2 ) is required to reduce the risk of radiation below the Space Permitted Exposure Limit (SPEL) (156)