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The production of deoxythymidine monophosphate (dTMP) through the reductive methylation of deoxyuridine monophosphate (dUMP) is performed by thymidylate synthase (TS) using the methyl moiety from 5,10-CH2-THF, thereby converting it into dihydrofolate (DHF)

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This strategy holds promise for addressing the vulnerability of conventional cancer therapy resulting from the persistence of senescent cancer cells

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Amal H, et al