Weight loss alone does not fully capture the biochemical adaptations occurring during prolonged GLP-1RA therapy, particularly those related to substrate redistribution, redox balance, and micronutrient-dependent metabolic processes
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A 10-year longitudinal follow-up study conducted at our research center on a cohort consisting of 159 patients with PCOS exhibited that long-term metformin treatment in overweight-obese women with PCOS led to a reduction and stabilization of body weight ( The weight trajectory after discontinuation of short-term semaglutide treatment in obese women with PCOS who continued metformin treatment has not yet been evaluated, so we can only provide a comparison with the general population from the STEP 1 extension study
American association of clinical endocrinologists and American College of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity
Diabetologia 59 , 14121421 (2016)