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2.3 Transmembrane domain (TMD) iGluRs are members of the pore-loop superfamily of tetrameric ion channels, sharing structural homology with potassium channels, voltage-gated sodium and calcium channels, cyclic nucleotide-gated (CNG) channels, and transient receptor potential (TRP) channels

GSTO1 knockdown as well as the small-molecule GSTO1 inhibitor C1-27 also caused downregulation of the Wnt inhibitor Dickkopf 1 ( DKK1 ), thombospondin 1 ( THBS1 ), the cysteine-rich angiogenic inducer CYR61 and caveolae scaffolding proteins CAV1 and CAV2 , among others