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46 Overexpression of efflux transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) in tumors limits intracellular drug accumulation, while physical barriers such as the bloodbrain barrier constrain effective delivery to sites such as gliomas

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Madeira F, Madhusoodanan N, Lee J, Eusebi A, Niewielska A, Tivey ARN, et al

This persistent cellular toxicity drives ongoing neuroinflammation, cognitive impairment (brain fog), and autonomic nervous system dysfunction, creating the complex web of symptoms that define Long COVID