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Symptoms of a vitamin B12 deficiency include fatigue, lacking energy, loss of appetite, headache, mouth ulcers, changes in vision, feelings of depression, and hindered mental capabilities
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Citrullinated peptides generated by peptidylarginine deiminase (PAD) enzyme trigger anti-CCP antibody production in genetically susceptible individuals
We suppose the change is because the initial doses are enough to keep B12 levels within the desired range
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