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liraglutide, semaglutide) (35, 37) acutely reduce food intake in rodents

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However, Compound 12 was unfortunately identified as a substrate of multidrug resistance protein 1 (MDR1, P-gp) in MadinDarby canine kidney (MDCK) cells with an efflux ratio greater than 5, which precluded its development as a candidate for CNS drugs