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Certain medical conditions and surgeries can hinder the bodys ability to produce it, leading to an increased risk of vitamin B12 deficiency
Despite the fact that it has been known for over 40 years that there is a requirement for Methylation in the production of melatonin via the enzyme HIOMT (Pevet etal, 1980), treatment for poor sleep in ASD by correction of functional B12 deficiency is generally not attempted (Souders etal, 2017
The copper ion binding that gives this compound its distinctive blue color and biological activity also makes it sensitive to factors that wouldn't affect simpler peptides
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Common applications in practitioner protocols
Clinical Nutrition, 38(4), 1747-1755
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