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These effects typically resolve within hours and decrease with continued use as skin adapts

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In the pancreas, activation stimulates glucose-dependent insulin secretion, meaning insulin is released only when blood glucose levels are elevated, which reduces the risk of hypoglycemia compared to some other diabetes medications

9 g/day for 6 months raised mortality in a 153-patient post-infarction trial[16]L-Arginine in Post-MI VINTAGE Trial JAMA (2006) View source

They reduce appetite and caloric intake by acting on the brains satiety centers, slow gastric emptying (keeping one full longer), and improve glycemic control