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Compared to bupropion-naltrexone, GLP-1 agonists were associated with a: 9.09 times higher risk of pancreatitis , or inflammation of the pancreas, which can cause severe abdominal pain and, in some cases, require hospitalization and surgery
This compound has gained significant attention in preclinical and early clinical research due to its promising effects on body weight reduction, insulin sensitivity improvement, and lipid profile enhancement
GLP-1 also plays a role to reduce slow gastric emptying
It belongs to a novel class of agents known as triple receptor agonists, meaning it simultaneously activates three distinct hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
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